Perioperative Testosterone Supplementation Improves Outcomes of Orthopaedic Surgeries: A Systematic Review of Heterogeneous Studies
Authors
Flynn ME, Cohen MF, O'Brien EJ, Domb BG
Objective
To evaluate the effect of testosterone supplementation during the perioperative period on outcomes following orthopedic surgery.
Methodology
A systematic review of 5 randomized controlled trials (4 Level I, 1 Level II) examining testosterone supplementation during orthopedic procedures such as hip fracture fixation, ACL reconstruction, and total knee arthroplasty.
Key Findings
- Four out of five trials found that testosterone improved body composition, bone mineral density (BMD), strength, functional scores, and patient independence.
- One small study showed no significant differences.
- Study protocols varied significantly in dosage, population, and outcome measures.
Conclusion
Testosterone supplementation may improve recovery, strength, and independence after orthopedic surgery, particularly in select populations. However, treatment should be tailored to the individual, given the variability in outcomes.
What Does This Mean For Patients
Testosterone supplementation could enhance recovery following surgery, especially in certain patients. It’s important to discuss this treatment option with your surgeon, as it may not be suitable for everyone.